Avoid Unnecessary tradeoffs
Introducing Prequel with AMPLIFY Technology. Demonstrated accuracy across all types of patients with our noninvasive prenatal screen.
Early Insights
Watch this patient story to hear how noninvasive prenatal screening can give a patient like Hannah, early insights into her pregnancy to help prepare her family.
About the Prequel Prenatal Screen
The Myriad Prequel Prenatal Screen is a noninvasive prenatal screen that uses cell-free DNA (cfDNA) to determine if a pregnancy is at an increased risk for common chromosome abnormalities, such as Down syndrome.
cfDNA screening has been shown to be superior to methods that use maternal age, ultrasound, and serum screening. This results in a lower false-positive rate and false-negative rate.5
The Prequel Prenatal Screen can be ordered together with the Foresight® Carrier Screen and offered to all women, including those with high BMI, an ovum donor or a twin pregnancy. Prequel can now provide individual fetal sex information for twins, in addition to singletons.
Prequel Test Details
Conditions covered
Common aneuploidies: Trisomy 21, Trisomy 18, Trisomy 13.
Optional analysis of sex chromosomes (which includes the ability to determine fetal sex for singletons and twins), microdeletions, and expanded aneuploidies.
Who to screen
All pregnant women
When to screen
As early as 10 weeks into pregnancy
Sample type
One tube of blood
Turnaround time
Results in ~ 1 week
Methodology
Whole-genome sequencing
Together, with
Myriad Women's Health
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- Noninvasive Prenatal Screening for Fetal Aneuploidy, 2016 Update: A Position Statement of the American College of Medical Genetics and Genomics. Obstetrical and Gynecological Survey. 2017 Jan 1;72(1):6-8.
- Hancock et al. (2019) Clinical experience across the fetal-fraction spectrum for a noninvasive prenatal screen with low test-failure
rate. UOG. doi/pdf/10.1002/uog.21904 - Muzzey et al. ( 2019). Noninvasive prenatal screening for patients with high body mass index: Evaluating the impact of a customized whole genome sequencing workflow on sensitivity and residual risk. Prenatal Diagnosis. Doi/abs/10.1002/pd.5603.
- Norton, M. et al Cell free DNA analysis for noninvasive examination of trisomy. The New England Journal of Medicine April 2015; 372: 1589-1597.6.Bianchi DW, Platt LD, Goldberg JD, Abuhamad AZ, Sehnert AJ, Rava Genome-wide fetal aneuploidy detection by maternal plasma DNA sequencing. Obstet Gynecol 2012, 119(5):890-901.
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- Illumina, Inc. Analytical Validation of the verifi® prenatal test: Enhanced Test Performance for Detecting Trisomies 21, 18, and 13 and the Option for Classification of Sex Chromosome Status. 2012.
- Liao H, Liu S, Wang H. Performance of non-invasive prenatal screening for fetal aneuploidy in twin pregnancies: a meta-analysis. Prenat Diagn. 2017;37: 874-882.
- Rodis JF, Egan JF, Craffey A, Ciarleglio L, Greenstein RM, Scorza WE. Calculated risk of chromosomal abnormalities in twin gestations. Obstet Gynecol. 1990;76: 1037-1041.
- Simpson LL. Twin-twin transfusion syndrome. Am J Obstet Gynecol. Elsevier; 2013;208: 3-18.
- Snijders RJM, Sundberg K, Holzgreve W, Henry G, Nicolaides KH. Maternal age and gestation-specific risk for trisomy 21. Ultrasound Obstet Gynecol 1999;13:167-70.
- Snijders RJM, Sebire NJ, Cuckle H, Nicolaides KH. Maternal age and gestation age-specific risks for chromosomal defects. Fetal Diag Ther 1995;10:356-67.