Myriad Prequel™ Prenatal Screen

Early, noninvasive insights into your pregnancy

As early as week 10, find out if your baby has an increased chance for chromosome conditions like Down syndrome.

Lacey O.
Myriad Prequel Prenatal Screen patient


Early insight into your baby’s development

If you’re pregnant, the Myriad Prequel Prenatal Screen is a noninvasive test that you can take as early as 10 weeks into your pregnancy to learn about your baby’s chance to have a chromosome condition like Down syndrome.

  • The Prequel Prenatal Screen looks at the chances for chromosome conditions, which are usually not inherited, in a current pregnancy. If you are also interested in learning about inherited conditions that you and your partner might pass on to a child, explore more about the Myriad Foresight® Carrier Screen.

A noninvasive way to screen for chromosome conditions

Normal developmental processes cause small pieces of DNA from your baby’s placenta to enter your bloodstream. By analyzing these fragments, called cell-free DNA, we can determine the chance that your baby has a chromosome condition. All that’s needed is a simple blood draw from your arm.

You should work with your healthcare provider to determine which conditions you would like included in your screen.

Chromosome conditions can have varying outcomes


Most babies have 46 chromosomes, 23 from each parent. Occasionally, a baby will have an extra chromosome, which can lead to health issues including birth defects and intellectual disabilities. This is called a trisomy. Down syndrome is an example of a trisomy.

Sex chromosome differences

The sex chromosomes determine whether a baby will be male (XY) or female (XX). Sometimes there may be too many or too few sex chromosomes, resulting in potential health issues.


Sometimes a tiny piece of a chromosome is missing. This is called a microdeletion. Microdeletions can lead to birth defects and intellectual disabilities.

Why get screened

Noninvasive prenatal screening gives you important information

Most women get reassuring results that their pregnancy is at low risk for chromosome condition. If your screen turns up something unusual, your healthcare provider will discuss what it means and will offer a follow-up diagnostic procedure to confirm the results. This may be chorionic villus sampling (CVS) or amniocentesis.

  • What is the difference between a screening and a diagnostic test?
    The Prequel Prenatal Screen is a screening test, not a diagnostic test. This means it cannot give a definitive answer as to whether or not your pregnancy is affected by a chromosome condition. To confirm positive screening results, you will need to have a follow-up diagnostic test.

There are many things you can do to plan and prepare

Whether or not you choose to have diagnostic testing after a positive screen you can:

Speak to a specialist

Knowing your child requires a certain type of care before birth means you can involve the right kind of specialist long before delivery.

Find the right place to deliver

You might want to seek out a specialized facility that is equipped to manage newborns with chromosome conditions.

Surround yourself with support

You may simply want to talk with one of our genetic counselors or work with a support group to understand what could lie ahead.

Speak to a genetic counselor >


We strive to make genetic screening more accessible

Myriad Women’s Health is in-network with most major insurance plans. We also have financial assistance and payment plans to help you handle a high deductible if you have one.

Why Myriad Prequel

Clear, actionable results

We are dedicated to making noninvasive prenatal screening available to all women. The Prequel Prenatal Screen has the lowest test failure rate in the industry, which translates to a lower chance of needing a repeat test or an unnecessary invasive diagnostic procedure. We use advanced science and technology that works for pregnant women of all ages, including those with twin and IVF pregnancies.

A simple blood draw can provide valuable insight

The Myriad Prequel Prenatal Screen is ordered by your healthcare provider. All we need is a simple blood draw from your arm, causing no increased risk to you or your pregnancy. Results are available in approximately 1 week.

Putting your results in context

A series of educational videos and an on-demand or scheduled consultation with one of our board-certified genetic counselors is available with every Prequel Prenatal Screen. Genetic counselors are specially-educated professionals who can provide the personalized help you may need to better understand your results and make informed choices.

Learn more about our genetic counselors ›


Understand your prenatal screening options

Talk to your healthcare provider about noninvasive prenatal screening using cell-free DNA. Your provider can help you understand more about screening and how you’ll be able to use the results as you plan for your future.

We’re here to help
View our FAQs to learn more.